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KMID : 0613820070170030427
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Journal of Life Science
2007 Volume.17 No. 3 p.427 ~ p.434
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Effect of Some Herbal Plant Extracts on the Activation of Dendritic Cells
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Kim Do-Soon
Cho Hyun-Wook
Joo Woo-Hong
Lee Sung-Tae
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Abstract
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Dendritic cells (DCs) play a pivotal roles in the initiation of T cell-mediated immune responses, making them an attractive in immuno vaccines. Angelica gigas and Cnidium officinale were a medicinal herb widely used in Asian countries. In this study, we examined the effects of A. gigas and C. officinale extracts on the DCs functional maturation and pheno-type. Immature DCs were cultured in the presence of GM-CSF and IL-4, and the generated immature DCs were stimulated with OVA in the presence or absence A. gigas and C. officinale extracts, respectively, for 24 hours. The antigen-presenting capacity of A. gigas and C. officinale extracts-treated DCs as analyzed by CD4+ helper T cell clone (OVA-specific) proliferation and cytokines (IL-2 and IFN-γ) production were significantly increased. But A. gigas and C. officinale extracts were not directly effected CD4+ helper T cell clone function. Also, the expression of surface co-stimulatory molecules, including major histocompatibility complex (MHC) class Ⅱ, CD86 and CD11c, is increased on DCs that were stimulated with A. gigas and C. officinale extracts. These results indicate the immunomodulatory properties of A. gigas and C. officinale extracts, which might be medical supplies or health foods.
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KEYWORD
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dendritic cells, Angelica gigas, Cnidium officinale, co-stimulatory molecules, cytokines
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